Coding GPCR-G protein specificity

Por Furness, Sebastian GB, Sexton, Patrick M
Publicado no Cell Res (2017)

Effects of urea pretreatment on the binding properties of adenosine A(1) receptors

Por May, Lauren T, Sexton, Patrick M, Christopoulos, Arthur
Publicado em 2005

Allosteric Modulation of Muscarinic Acetylcholine Receptors

Por Gregory, Karen J, Sexton, Patrick M, Christopoulos, Arthur
Publicado em 2007

Novel Allosteric Modulators of G Protein-coupled Receptors

Por Gentry, Patrick R., Sexton, Patrick M., Christopoulos, Arthur
Publicado no J Biol Chem (2015)

What determines the magnitude of cellular response for activation of G protein-coupled receptors?

Por Furness, Sebastian G. B., Wootten, Denise, Sexton, Patrick M.
Publicado no Cell Cycle (2017)

Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor

Por Gao, Fan, Sexton, Patrick M., Christopoulos, Arthur, Miller, Laurence J.
Publicado em 2008

Consequences of splice variation on Secretin family G protein-coupled receptor function

Por Furness, Sebastian GB, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick M
Publicado em 2012

Stimulus Bias Provides Evidence for Conformational Constraints in the Structure of a G Protein-coupled Receptor

Por Gregory, Karen J., Sexton, Patrick M., Tobin, Andrew B., Christopoulos, Arthur
Publicado em 2012

Structural Determinants of Allosteric Agonism and Modulation at the M(4) Muscarinic Acetylcholine Receptor: IDENTIFICATION OF LIGAND-SPECIFIC AND GLOBAL ACTIVATION MECHANISMS

Por Nawaratne, Vindhya, Leach, Katie, Felder, Christian C., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2010

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

Por Harikumar, Kaleeckal G., Ball, Alicja M., Sexton, Patrick M., Miller, Laurence J.
Publicado em 2010

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Por Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado em 2013

Pattern of Intra-Family Hetero-Oligomerization Involving the G-Protein-Coupled Secretin Receptor

Por Harikumar, Kaleeckal G., Morfis, Maria M., Sexton, Patrick M., Miller, Laurence J.
Publicado em 2008

THE MOLECULAR BASIS OF ASSOCIATION OF RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 WITH THE FAMILY B G PROTEIN-COUPLED SECRETIN RECEPTOR

Por Harikumar, Kaleeckal G., Simms, John, Christopoulos, George, Sexton, Patrick M., Miller, Laurence J.
Publicado em 2009

Identification of Orthosteric and Allosteric Site Mutations in M(2) Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

Por Gregory, Karen J., Hall, Nathan E., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2010

Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation

Por Koole, Cassandra, Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado em 2012

β-Arrestin-biased agonists of the GLP-1 receptor from β-amino acid residue incorporation into GLP-1 analogues

Por Hager, Marlies V., Johnson, Lisa M., Wootten, Denise, Sexton, Patrick M., Gellman, Samuel H.
Publicado no J Am Chem Soc (2016)

A Monod-Wyman-Changeux Mechanism Can Explain G Protein-coupled Receptor (GPCR) Allosteric Modulation

Por Canals, Meritxell, Lane, J. Robert, Wen, Adriel, Scammells, Peter J., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2012

Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery

Por Koole, Cassandra, Savage, Emilia E., Christopoulos, Arthur, Miller, Laurence J., Sexton, Patrick M., Wootten, Denise
Publicado em 2013

Polymorphism and Ligand Dependent Changes in Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Function: Allosteric Rescue of Loss of Function Mutation

Por Koole, Cassandra, Wootten, Denise, Simms, John, Valant, Celine, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado em 2011

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP...

Por Koole, Cassandra, Reynolds, Christopher A., Mobarec, Juan C., Hick, Caroline, Sexton, Patrick M., Sakmar, Thomas P.
Publicado no J Biol Chem (2017)