Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation

The glucagon-like peptide-1 receptor (GLP-1R) is a therapeutically important family B G protein-coupled receptor (GPCR) that is pleiotropically coupled to multiple signaling effectors and, with actions including regulation of insulin biosynthesis and secretion, is one of the key targets in the manag...

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Hlavní autoři: Koole, Cassandra, Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281720/
https://ncbi.nlm.nih.gov/pubmed/22147710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.309328
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