Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

G protein–coupled receptors (GPCRs) can be differentially activated by ligands to generate multiple and distinct downstream signaling profiles, a phenomenon termed biased agonism. The glucagon-like peptide-1 receptor (GLP-1R) is a class B GPCR and a key drug target for managing metabolic disorders;...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lei, Saifei, Clydesdale, Lachlan, Dai, Antao, Cai, Xiaoqing, Feng, Yang, Yang, Dehua, Liang, Yi-Lynn, Koole, Cassandra, Zhao, Peishen, Coudrat, Thomas, Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise, Sexton, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005446/
https://ncbi.nlm.nih.gov/pubmed/29717000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003278
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