Polymorphism and Ligand Dependent Changes in Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Function: Allosteric Rescue of Loss of Function Mutation

The glucagon-like peptide-1 receptor (GLP-1R) is a key physiological regulator of insulin secretion and a major therapeutic target for the treatment of type II diabetes. However, regulation of GLP-1R function is complex with multiple endogenous peptides that interact with the receptor, including ful...

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Main Authors: Koole, Cassandra, Wootten, Denise, Simms, John, Valant, Celine, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364496/
https://ncbi.nlm.nih.gov/pubmed/21616920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.072884
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