Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery

The glucagon-like peptide-1 receptor (GLP-1R) controls the physiological responses to the incretin hormone glucagon-like peptide-1 and is a major therapeutic target for the treatment of type 2 diabetes, owing to the broad range of effects that are mediated upon its activation. These include the prom...

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Bibliographic Details
Main Authors: Koole, Cassandra, Savage, Emilia E., Christopoulos, Arthur, Miller, Laurence J., Sexton, Patrick M., Wootten, Denise
Format: Artigo
Language:Inglês
Published: Endocrine Society 2013
Subjects:
Minireviews
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725346/
https://ncbi.nlm.nih.gov/pubmed/23864649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1116
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