The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding to intracellular signaling. Activation of class B G protein...

詳細記述

保存先:
書誌詳細
出版年:Cell
主要な著者: Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
フォーマット: Artigo
言語:Inglês
出版事項: Cell Press 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912689/
https://ncbi.nlm.nih.gov/pubmed/27315480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.023
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