Computational modeling, docking and molecular dynamics of the transcriptional activator ComA bound to a newly-identified functional DNA binding site

Por Mobarec, Juan C, Wolf, Diana, Bischofs, Ilka B, Kolb, Peter
Publicado em 2014

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH(2)) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

Por Weaver, Richard E., Mobarec, Juan C., Wigglesworth, Mark J., Reynolds, Christopher A., Donnelly, Dan
Publicado no Biochem Pharmacol (2017)

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP...

Por Koole, Cassandra, Reynolds, Christopher A., Mobarec, Juan C., Hick, Caroline, Sexton, Patrick M., Sakmar, Thomas P.
Publicado no J Biol Chem (2017)

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in...

Por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G.B., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado no Biochem Pharmacol (2016)

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

Por Wootten, Denise, Reynolds, Christopher A., Koole, Cassandra, Smith, Kevin J., Mobarec, Juan C., Simms, John, Quon, Tezz, Coudrat, Thomas, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado no Mol Pharmacol (2016)

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado no Cell (2016)