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Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

The glucagon-like peptide-1 receptor (GLP-1R) is a key therapeutic target in the management of type II diabetes mellitus, with actions including regulation of insulin biosynthesis and secretion, promotion of satiety, and preservation of β-cell mass. Like most class B G protein-coupled receptors (GPC...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Koole, Cassandra, Reynolds, Christopher A., Mobarec, Juan C., Hick, Caroline, Sexton, Patrick M., Sakmar, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409479/
https://ncbi.nlm.nih.gov/pubmed/28283573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.779496
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