Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a major therapeutic target for treatment of diabetes. However, GLP-1 receptor function is complex, with multiple endogenous peptides that can interact with the receptor, including full-length (1–37) and truncate...

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Auteurs principaux: Koole, Cassandra, Wootten, Denise, Simms, John, Valant, Celine, Sridhar, Rohan, Woodman, Owen L., Miller, Laurence J., Summers, Roger J., Christopoulos, Arthur, Sexton, Patrick M.
Format: Artigo
Langue:Inglês
Publié: American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202488/
https://ncbi.nlm.nih.gov/pubmed/20547734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065664
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