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Stimulus Bias Provides Evidence for Conformational Constraints in the Structure of a G Protein-coupled Receptor

A key characteristic of G protein-coupled receptors (GPCRs) is that they activate a plethora of signaling pathways. It is now clear that a GPCR coupling to these pathways can be regulated selectively by ligands that differentially drive signaling down one pathway in preference to another. This conce...

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Autores principales: Gregory, Karen J., Sexton, Patrick M., Tobin, Andrew B., Christopoulos, Arthur
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481307/
https://ncbi.nlm.nih.gov/pubmed/22965232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.408534
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