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Stimulus Bias Provides Evidence for Conformational Constraints in the Structure of a G Protein-coupled Receptor
A key characteristic of G protein-coupled receptors (GPCRs) is that they activate a plethora of signaling pathways. It is now clear that a GPCR coupling to these pathways can be regulated selectively by ligands that differentially drive signaling down one pathway in preference to another. This conce...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3481307/ https://ncbi.nlm.nih.gov/pubmed/22965232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.408534 |
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