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Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor

The cholecystokinin (CCK(1)) receptor is a G protein-coupled receptor important for nutrient homeostasis. The molecular basis of CCK-receptor binding has been debated, with one prominent model suggesting occupation of the same region of the intramembranous helical bundle as benzodiazepines. Here, we...

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Autors principals: Gao, Fan, Sexton, Patrick M., Christopoulos, Arthur, Miller, Laurence J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528863/
https://ncbi.nlm.nih.gov/pubmed/18621527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.06.053
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