Molecular Basis for Benzodiazepine Agonist Action at the Type 1 Cholecystokinin Receptor

Understanding the molecular basis of drug action can facilitate development of more potent and selective drugs. Here, we explore the molecular basis for action of a unique small molecule ligand that is a type 1 cholecystokinin (CCK) receptor agonist and type 2 CCK receptor antagonist, GI181771X. We...

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Detalhes bibliográficos
Main Authors: Harikumar, Kaleeckal G., Cawston, Erin E., Lam, Polo C. H., Patil, Achyut, Orry, Andrew, Henke, Brad R., Abagyan, Ruben, Christopoulos, Arthur, Sexton, Patrick M., Miller, Laurence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774375/
https://ncbi.nlm.nih.gov/pubmed/23754289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480715
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