A Type 1 Cholecystokinin Receptor Mutant That Mimics the Dysfunction Observed for Wild Type Receptor in a High Cholesterol Environment

Cholecystokinin (CCK) stimulates the type 1 CCK receptor (CCK1R) to elicit satiety after a meal. Agonists with this activity, although potentially useful for treatment of obesity, can also have side effects and toxicities of concern, making the development of an intrinsically inactive positive allos...

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Autors principals: Desai, Aditya J., Harikumar, Kaleeckal G., Miller, Laurence J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140287/
https://ncbi.nlm.nih.gov/pubmed/24825903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570200
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