Molecular Mechanisms of Action and In Vivo Validation of an M(4) Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties

We recently identified LY2033298 as a novel allosteric potentiator of acetylcholine (ACh) at the M(4) muscarinic acetylcholine receptor (mAChR). This study characterized the molecular mode of action of this modulator in both recombinant and native systems. Radioligand-binding studies revealed that L...

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Autors principals: Leach, Katie, Loiacono, Richard E, Felder, Christian C, McKinzie, David L, Mogg, Adrian, Shaw, David B, Sexton, Patrick M, Christopoulos, Arthur
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055367/
https://ncbi.nlm.nih.gov/pubmed/19940843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.194
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