Probing the binding site of novel selective positive allosteric modulators at the M(1) muscarinic acetylcholine receptor

Subtype-selective allosteric modulation of the M(1) muscarinic acetylcholine (ACh) receptor (M(1) mAChR) is an attractive approach for the treatment of numerous disorders, including cognitive deficits. The discovery of benzyl quinolone carboxylic acid, BQCA, a selective M(1) mAChR positive allosteri...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem Pharmacol
Prif Awduron: Khajehali, Elham, Valant, Celine, Jörg, Manuela, Tobin, Andrew B., Conn, P. Jeffrey, Lindsley, Craig W., Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Science 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066355/
https://ncbi.nlm.nih.gov/pubmed/29777683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.05.009
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