Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M(1) Muscarinic Acetylcholine Receptors

Positive allosteric modulators (PAMs) that target the M(1) muscarinic acetylcholine (ACh) receptor (M(1) mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer disease and schizophrenia. We recently reported novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one M(1...

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Publicado en:Mol Pharmacol
Autores principales: van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine, Christopoulos, Arthur
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616191/
https://ncbi.nlm.nih.gov/pubmed/29691279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.111633
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