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Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M(1) Muscarinic Acetylcholine Receptors

Positive allosteric modulators (PAMs) that target the M(1) muscarinic acetylcholine (ACh) receptor (M(1) mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer disease and schizophrenia. We recently reported novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one M(1...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine, Christopoulos, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616191/
https://ncbi.nlm.nih.gov/pubmed/29691279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.111633
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