Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl) pyridine positive allosteric modulators for the M(4) mAChR

Translation of muscarinic acetylcholine receptor (mAChR) agonists into clinically used therapeutic agents has been difficult due to their poor subtype selectivity. M(4) mAChR subtype-selective positive allosteric modulators (PAMs) may provide better therapeutic outcomes, hence investigating their de...

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Publicat a:Eur J Med Chem
Autors principals: Jörg, Manuela, van der Westhuizen, Emma T., Lu, Yao, Choy, K.H. Christopher, Shackleford, David M., Khajehali, Elham, Tobin, Andrew B., Thal, David M., Capuano, Ben, Christopoulos, Arthur, Valant, Celine, Scammells, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: 2023
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616163/
https://ncbi.nlm.nih.gov/pubmed/37423123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2023.115588
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