Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl) pyridine positive allosteric modulators for the M(4) mAChR

Translation of muscarinic acetylcholine receptor (mAChR) agonists into clinically used therapeutic agents has been difficult due to their poor subtype selectivity. M(4) mAChR subtype-selective positive allosteric modulators (PAMs) may provide better therapeutic outcomes, hence investigating their de...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Jörg, Manuela, van der Westhuizen, Emma T., Lu, Yao, Choy, K.H. Christopher, Shackleford, David M., Khajehali, Elham, Tobin, Andrew B., Thal, David M., Capuano, Ben, Christopoulos, Arthur, Valant, Celine, Scammells, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2023
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616163/
https://ncbi.nlm.nih.gov/pubmed/37423123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2023.115588
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados