Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl) pyridine positive allosteric modulators for the M(4) mAChR

Translation of muscarinic acetylcholine receptor (mAChR) agonists into clinically used therapeutic agents has been difficult due to their poor subtype selectivity. M(4) mAChR subtype-selective positive allosteric modulators (PAMs) may provide better therapeutic outcomes, hence investigating their de...

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Опубликовано в: :Eur J Med Chem
Главные авторы: Jörg, Manuela, van der Westhuizen, Emma T., Lu, Yao, Choy, K.H. Christopher, Shackleford, David M., Khajehali, Elham, Tobin, Andrew B., Thal, David M., Capuano, Ben, Christopoulos, Arthur, Valant, Celine, Scammells, Peter J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2023
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616163/
https://ncbi.nlm.nih.gov/pubmed/37423123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2023.115588
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