Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl) pyridine positive allosteric modulators for the M(4) mAChR

Translation of muscarinic acetylcholine receptor (mAChR) agonists into clinically used therapeutic agents has been difficult due to their poor subtype selectivity. M(4) mAChR subtype-selective positive allosteric modulators (PAMs) may provide better therapeutic outcomes, hence investigating their de...

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Bibliografiska uppgifter
I publikationen:Eur J Med Chem
Huvudupphovsmän: Jörg, Manuela, van der Westhuizen, Emma T., Lu, Yao, Choy, K.H. Christopher, Shackleford, David M., Khajehali, Elham, Tobin, Andrew B., Thal, David M., Capuano, Ben, Christopoulos, Arthur, Valant, Celine, Scammells, Peter J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2023
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616163/
https://ncbi.nlm.nih.gov/pubmed/37423123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2023.115588
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