Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl) pyridine positive allosteric modulators for the M(4) mAChR

Translation of muscarinic acetylcholine receptor (mAChR) agonists into clinically used therapeutic agents has been difficult due to their poor subtype selectivity. M(4) mAChR subtype-selective positive allosteric modulators (PAMs) may provide better therapeutic outcomes, hence investigating their de...

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Détails bibliographiques
Publié dans:Eur J Med Chem
Auteurs principaux: Jörg, Manuela, van der Westhuizen, Emma T., Lu, Yao, Choy, K.H. Christopher, Shackleford, David M., Khajehali, Elham, Tobin, Andrew B., Thal, David M., Capuano, Ben, Christopoulos, Arthur, Valant, Celine, Scammells, Peter J.
Format: Artigo
Langue:Inglês
Publié: 2023
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616163/
https://ncbi.nlm.nih.gov/pubmed/37423123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2023.115588
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