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Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M(1) Muscarinic Acetylcholine Receptors

Positive allosteric modulators (PAMs) that target the M(1) muscarinic acetylcholine (ACh) receptor (M(1) mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer disease and schizophrenia. We recently reported novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one M(1...

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書誌詳細
出版年:Mol Pharmacol
主要な著者: van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine, Christopoulos, Arthur
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616191/
https://ncbi.nlm.nih.gov/pubmed/29691279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.111633
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