Restoring Agonist Function at a Chemogenetically Modified M(1) Muscarinic Acetylcholine Receptor

Designer receptors exclusively activated by designer drugs (DREADDs) have been successfully employed to activate signaling pathways associated with specific muscarinic acetylcholine receptor (mAChR) subtypes. The M(1) DREADD mAChR displays minimal responsiveness to the endogenous agonist acetylcholi...

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Publicat a:ACS Chem Neurosci
Autors principals: Khajehali, Elham, Bradley, Sophie, van der Westhuizen, Emma T., Molloy, Colin, Valant, Celine, Finlayson, Lisa, Lindsley, Craig W., Sexton, Patrick M., Tobin, Andrew B., Christopoulos, Arthur
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616161/
https://ncbi.nlm.nih.gov/pubmed/33196174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00540
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