Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

The M(1) and M(4) muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia. Due to high sequence homology, selective targeting of any of the M(1)-M(5) mAChRs through the endogenous ligand binding si...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: van der Westhuizen, Emma T., Choy, K. H. Christopher, Valant, Celine, McKenzie-Nickson, Simon, Bradley, Sophie J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878563/
https://ncbi.nlm.nih.gov/pubmed/33584282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.606656
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