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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

The M(1) and M(4) muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia. Due to high sequence homology, selective targeting of any of the M(1)-M(5) mAChRs through the endogenous ligand binding si...

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Podrobná bibliografie
Vydáno v:Front Pharmacol
Hlavní autoři: van der Westhuizen, Emma T., Choy, K. H. Christopher, Valant, Celine, McKenzie-Nickson, Simon, Bradley, Sophie J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878563/
https://ncbi.nlm.nih.gov/pubmed/33584282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.606656
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