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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
The M(1) and M(4) muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia. Due to high sequence homology, selective targeting of any of the M(1)-M(5) mAChRs through the endogenous ligand binding si...
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| Udgivet i: | Front Pharmacol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7878563/ https://ncbi.nlm.nih.gov/pubmed/33584282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.606656 |
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