Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

The M(1) and M(4) muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia. Due to high sequence homology, selective targeting of any of the M(1)-M(5) mAChRs through the endogenous ligand binding si...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: van der Westhuizen, Emma T., Choy, K. H. Christopher, Valant, Celine, McKenzie-Nickson, Simon, Bradley, Sophie J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878563/
https://ncbi.nlm.nih.gov/pubmed/33584282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.606656
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