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Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

Recent breakthroughs and developments in structural biology have led to a spate of crystal structures for G protein–coupled receptors (GPCRs). This is the case for the muscarinic acetylcholine receptors (mAChRs) where inactive-state structures for four of the five subtypes and two active-state struc...

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Publicado en:J Gen Physiol
Autores principales: Burger, Wessel A.C., Sexton, Patrick M., Christopoulos, Arthur, Thal, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168235/
https://ncbi.nlm.nih.gov/pubmed/30190312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711979
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