Identification of a Novel Allosteric Site at the M(5) Muscarinic Acetylcholine Receptor

The M(5) muscarinic acetylcholine receptor (mAChR) has emerged as an exciting therapeutic target for the treatment of addiction and behavioral disorders. This has been in part due to promising preclinical studies with the M(5) mAChR selective negative allosteric modulator (NAM), ML375. The binding s...

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Pubblicato in:ACS Chem Neurosci
Autori principali: Burger, Wessel A. C., Gentry, Patrick R., Berizzi, Alice E., Vuckovic, Ziva, van der Westhuizen, Emma T., Thompson, Geoff, Yeasmin, Mahmuda, Lindsley, Craig W., Sexton, Patrick M., Langmead, Christopher J., Tobin, Andrew B., Christopoulos, Arthur, Valant, Celine, Thal, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616173/
https://ncbi.nlm.nih.gov/pubmed/34351123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00383
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