Identification of a Novel Allosteric Site at the M(5) Muscarinic Acetylcholine Receptor

The M(5) muscarinic acetylcholine receptor (mAChR) has emerged as an exciting therapeutic target for the treatment of addiction and behavioral disorders. This has been in part due to promising preclinical studies with the M(5) mAChR selective negative allosteric modulator (NAM), ML375. The binding s...

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Argitaratua izan da:ACS Chem Neurosci
Egile Nagusiak: Burger, Wessel A. C., Gentry, Patrick R., Berizzi, Alice E., Vuckovic, Ziva, van der Westhuizen, Emma T., Thompson, Geoff, Yeasmin, Mahmuda, Lindsley, Craig W., Sexton, Patrick M., Langmead, Christopher J., Tobin, Andrew B., Christopoulos, Arthur, Valant, Celine, Thal, David M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616173/
https://ncbi.nlm.nih.gov/pubmed/34351123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00383
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