Identification of a Novel Allosteric Site at the M(5) Muscarinic Acetylcholine Receptor

The M(5) muscarinic acetylcholine receptor (mAChR) has emerged as an exciting therapeutic target for the treatment of addiction and behavioral disorders. This has been in part due to promising preclinical studies with the M(5) mAChR selective negative allosteric modulator (NAM), ML375. The binding s...

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Publicado en:ACS Chem Neurosci
Main Authors: Burger, Wessel A. C., Gentry, Patrick R., Berizzi, Alice E., Vuckovic, Ziva, van der Westhuizen, Emma T., Thompson, Geoff, Yeasmin, Mahmuda, Lindsley, Craig W., Sexton, Patrick M., Langmead, Christopher J., Tobin, Andrew B., Christopoulos, Arthur, Valant, Celine, Thal, David M.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616173/
https://ncbi.nlm.nih.gov/pubmed/34351123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00383
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