Identification of a Novel Allosteric Site at the M(5) Muscarinic Acetylcholine Receptor

The M(5) muscarinic acetylcholine receptor (mAChR) has emerged as an exciting therapeutic target for the treatment of addiction and behavioral disorders. This has been in part due to promising preclinical studies with the M(5) mAChR selective negative allosteric modulator (NAM), ML375. The binding s...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Burger, Wessel A. C., Gentry, Patrick R., Berizzi, Alice E., Vuckovic, Ziva, van der Westhuizen, Emma T., Thompson, Geoff, Yeasmin, Mahmuda, Lindsley, Craig W., Sexton, Patrick M., Langmead, Christopher J., Tobin, Andrew B., Christopoulos, Arthur, Valant, Celine, Thal, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616173/
https://ncbi.nlm.nih.gov/pubmed/34351123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00383
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