From orphans to orexins: an arousing fifteen years

Por Langmead, Christopher J
Publicado em 2014

Supra-physiological efficacy at GPCRs: superstition or super agonists?

Por Langmead, Christopher J, Christopoulos, Arthur
Publicado em 2013

Matching models to data: a receptor pharmacologist's guide

Por Hall, David A, Langmead, Christopher J
Publicado em 2010

Learning generative models of molecular dynamics

Por Razavian, Narges Sharif, Kamisetty, Hetunandan, Langmead, Christopher J
Publicado em 2012

Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein Gα(o1) by the Ghr...

Por Bennett, Kirstie A., Langmead, Christopher J., Wise, Alan, Milligan, Graeme
Publicado em 2009

Progress in Structure Based Drug Design for G Protein-Coupled Receptors

Por Congreve, Miles, Langmead, Christopher J., Mason, Jonathan S., Marshall, Fiona H.
Publicado em 2011

Parameter discovery in stochastic biological models using simulated annealing and statistical model checking

Por Hussain, Faraz, Jha, Sumit K., Jha, Susmit, Langmead, Christopher J.
Publicado no Int J Bioinform Res Appl (2014)

Mutagenic Mapping Suggests a Novel Binding Mode for Selective Agonists of M(1) Muscarinic Acetylcholine Receptors

Por Lebon, Guillaume, Langmead, Christopher J., Tehan, Ben G., Hulme, Edward C.
Publicado em 2009

Efficient Modeling and Active Learning Discovery of Biological Responses

Por Naik, Armaghan W., Kangas, Joshua D., Langmead, Christopher J., Murphy, Robert F.
Publicado em 2013

Contrasting Effects of Allosteric and Orthosteric Agonists on M(1) Muscarinic Acetylcholine Receptor Internalization and Down-regulation

Por Thomas, Rachel L., Langmead, Christopher J., Wood, Martyn D., Challiss, R. A. John
Publicado em 2009

Discovering Conformational Sub-States Relevant to Protein Function

Por Ramanathan, Arvind, Savol, Andrej J., Langmead, Christopher J., Agarwal, Pratul K., Chennubhotla, Chakra S.
Publicado em 2011

Quantitative Analysis Reveals Multiple Mechanisms of Allosteric Modulation of the mGlu5 Receptor in Rat Astroglia

Por Bradley, Sophie J., Langmead, Christopher J., Watson, Jeannette M., Challiss, R. A. John
Publicado em 2011

Automated parameter estimation for biological models using Bayesian statistical model checking

Por Hussain, Faraz, Langmead, Christopher J, Mi, Qi, Dutta-Moscato, Joyeeta, Vodovotz, Yoram, Jha, Sumit K
Publicado no BMC Bioinformatics (2015)

The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies

Por Roberts, Claire, Allen, Lucy, Langmead, Christopher J, Hagan, Jim J, Middlemiss, Derek N, Price, Gary W
Publicado em 2001

Characterisation of the binding of [(3)H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

Por Langmead, Christopher J, Jerman, Jeffrey C, Brough, Stephen J, Scott, Claire, Porter, Rod A, Herdon, Hugh J
Publicado em 2003

Using Optical Markers of Non-dysplastic Rectal Epithelial Cells to Identify Patients With Ulcerative Colitis (UC) - Associated Neoplasia

Por Bista, Rajan K., Brentnall, Teresa A., Bronner, Mary P., Langmead, Christopher J., Brand, Randall E., Liu, Yang
Publicado em 2011

Pharmacology and Structure of Isolated Conformations of the Adenosine A(2A) Receptor Define Ligand Efficacy

Por Bennett, Kirstie A., Tehan, Benjamin, Lebon, Guillaume, Tate, Christopher G., Weir, Malcolm, Marshall, Fiona H., Langmead, Christopher J.
Publicado em 2013

Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation

Por Lebon, Guillaume, Warne, Tony, Edwards, Patricia C., Bennett, Kirstie, Langmead, Christopher J., Leslie, Andrew G.W., Tate, Christopher G.
Publicado em 2011

The Marker State Space (MSS) Method for Classifying Clinical Samples

Por Fallon, Brian P., Curnutte, Bryan, Maupin, Kevin A., Partyka, Katie, Choi, Sunguk, Brand, Randall E., Langmead, Christopher J., Tembe, Waibhav, Haab, Brian B.
Publicado em 2013

Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor

Por Langmead, Christopher J, Szekeres, Philip G, Chambers, Jonathan K, Ratcliffe, Steven J, Jones, Declan N C, Hirst, Warren D, Price, Gary W, Herdon, Hugh J
Publicado em 2000