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Contrasting Effects of Allosteric and Orthosteric Agonists on M(1) Muscarinic Acetylcholine Receptor Internalization and Down-regulation

A new class of subtype-selective muscarinic acetylcholine (mACh) receptor agonist that activates the receptor through interaction at a site distinct from the orthosteric acetylcholine binding site has been reported recently. Here, we have compared the effects of orthosteric (oxotremorine-M, arecolin...

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Autori principali: Thomas, Rachel L., Langmead, Christopher J., Wood, Martyn D., Challiss, R. A. John
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784718/
https://ncbi.nlm.nih.gov/pubmed/19767446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160242
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