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Supra-physiological efficacy at GPCRs: superstition or super agonists?
The concept of ‘super agonism’ has been described since the discovery of peptide hormone analogues that yielded greater functional responses than the endogenous agonists, in the early 1980s. It has remained an area of debate as to whether such compounds can really display greater efficacy than an en...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Publishing Ltd
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651661/ https://ncbi.nlm.nih.gov/pubmed/23441648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12142 |
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