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Pharmacology and Structure of Isolated Conformations of the Adenosine A(2A) Receptor Define Ligand Efficacy
Using isolated receptor conformations crystal structures of the adenosine A(2A) receptor have been solved in active and inactive states. Studying the change in affinity of ligands at these conformations allowed qualitative prediction of compound efficacy in vitro in a system-independent manner. Agon...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3629831/ https://ncbi.nlm.nih.gov/pubmed/23429888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.084509 |
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