The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease

[Image: see text] T-Type Ca(2+) channel inhibitors hold tremendous therapeutic potential for the treatment of pain, epilepsy, sleep disorders, essential tremor, and other neurological disorders; however, a lack of truly selective tools has hindered basic research, and selective tools from the pharma...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Xiang, Zixiu, Thompson, Analisa D., Brogan, John T., Schulte, Michael L., Melancon, Bruce J., Mi, Debbie, Lewis, L. Michelle, Zou, Bende, Yang, Liya, Morrison, Ryan, Santomango, Tammy, Byers, Frank, Brewer, Katrina, Aldrich, Jonathan S., Yu, Haibo, Dawson, Eric S., Li, Min, McManus, Owen, Jones, Carrie K., Daniels, J. Scott, Hopkins, Corey R., Xie, Ximin Simon, Conn, P. Jeffrey, Weaver, C. David, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285241/
https://ncbi.nlm.nih.gov/pubmed/22368764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200090z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados