Enhanced Dynamics of HIV gp120 Glycoprotein by Small Molecule Binding

Por Shrivastava, Indira, LaLonde, Judith M.
Publicado em 2011

Fluctuation Dynamics Analysis of gp120 Envelope Protein Reveals a Topologically Based Communication Network

Por Shrivastava, Indira, LaLonde, Judith M.
Publicado em 2010

Spontaneous Rearrangement of the β20/β21 Strands in Simulations of Unliganded HIV-1 Glycoprotein, gp120

Por Shrivastava, Indira, Wendel, Kaylee, LaLonde, Judith M.
Publicado em 2012

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1

Por Flick, Hollie E., LaLonde, Judith M., Malachowski, William P., Muller, Alexander J.
Publicado em 2013

Structure Based Development of Phenyl-imidazole-derived Inhibitors of Indoleamine 2,3-Dioxygenase

Por Kumar, Sanjeev, Jaller, Daniel, Patel, Bhumika, LaLonde, Judith M., DuHadaway, James B., Malachowski, William P., Prendergast, George C., Muller, Alexander J.
Publicado em 2008

Localized Changes in the gp120 Envelope Glycoprotein Confer Resistance to Human Immunodeficiency Virus Entry Inhibitors BMS-806 and #155

Por Madani, Navid, Perdigoto, Ana Luisa, Srinivasan, Kumar, Cox, Jason M., Chruma, Jason J., LaLonde, Judith, Head, Martha, Smith, Amos B., Sodroski, Joseph G.
Publicado em 2004

Active Core in a Triazole Peptide Dual Site Antagonist of HIV-1 gp120

Por Umashankara, Muddegowda, McFadden, Karyn, Zentner, Isaac, Schön, Arne, Rajagopal, Srivats, Tuzer, Ferit, Kuriakose, Syna A, Contarino, Mark, LaLonde, Judith, Freire, Ernesto, Chaiken, Irwin
Publicado em 2010

A model of the peptide triazole entry inhibitor binding to HIV-1 gp120 and mechanism of bridging sheet disruption

Por Emileh, Ali, Tuzer, Ferit, Yeh, Herman, Umashankara, Muddegowda, Moreira, Diogo R. M., LaLonde, Judith M., Bewley, Carole A., Abrams, Cameron F., Chaiken, Irwin M.
Publicado em 2013

HIV-1 Env gp120 Structural Determinants for Peptide Triazole Dual Receptor Site Antagonism

Por Tuzer, Ferit, Madani, Navid, Kamanna, Kantharaju, Zentner, Isaac, LaLonde, Judith, Holmes, Andrew, Upton, Elizabeth, Rajagopal, Srivats, McFadden, Karyn, Contarino, Mark, Sodroski, Joseph, Chaiken, Irwin
Publicado em 2012

Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors

Por Kumar, Sanjeev, Malachowski, William P., DuHadaway, James B., LaLonde, Judith M., Carroll, Patrick J., Jaller, Daniel, Metz, Richard, Prendergast, George C., Muller, Alexander J.
Publicado no J Med Chem (2008)

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Por Courter, Joel R., Madani, Navid, Sodroski, Joseph, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Hendrickson, Wayne A., Chaiken, Irwin M., LaLonde, Judith M., Smith, Amos B.
Publicado em 2014

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

Por Kwon, Young Do, LaLonde, Judith M., Yang, Yongping, Elban, Mark A., Sugawara, Akihiro, Courter, Joel R., Jones, David M., Smith, Amos B., Debnath, Asim K., Kwong, Peter D.
Publicado em 2014

O-Alkylhydroxylamines as Rationally-designed Mechanism-based Inhibitors of Indoleamine 2,3-Dioxygenase-1

Por Malachowski, William P., Winters, Maria, DuHadaway, James B., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Rahman, Maisha, Sheikh, Eesha, LaLonde, Judith M., Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J.
Publicado no Eur J Med Chem (2015)

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

Por LaLonde, Judith M., Elban, Mark A., Courter, Joel R., Sugawara, Akihiro, Soeta, Takahiro, Madani, Navid, Princiotto, Amy M., Kwon, Young Do, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Sodroski, Joseph, Smith, Amos B.
Publicado em 2010

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition

Por Melillo, Bruno, Liang, Shuaiyi, Park, Jongwoo, Schön, Arne, Courter, Joel R., LaLonde, Judith M., Wendler, Daniel J., Princiotto, Amy M., Seaman, Michael S., Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A., Smith, Amos B.
Publicado no ACS Med Chem Lett (2016)

Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-ray and Thermodynamic Characterization

Por LaLonde, Judith M., Le-Khac, Matthew, Jones, David M., Courter, Joel R., Park, Jongwoo, Schön, Arne, Princiotto, Amy M., Wu, Xueling, Mascola, John R., Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A., Smith, Amos B.
Publicado em 2013

Structural Determinants for Affinity Enhancement of a Dual Antagonist Peptide Entry Inhibitor of Human Immunodeficiency Virus Type-1

Por Gopi, Hosahudya, Umashankara, M., Pirrone, Vanessa, LaLonde, Judith, Madani, Navid, Tuzer, Ferit, Baxter, Sabine, Zentner, Isaac, Cocklin, Simon, Jawanda, Navneet, Miller, Shendra R., Schön, Arne, Klein, Jeffrey C., Freire, Ernesto, Krebs, Fred C., Smith, Amos B., Sodroski, Joseph, Chaiken, Irwin
Publicado em 2008

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies

Por Madani, Navid, Princiotto, Amy M., Schön, Arne, LaLonde, Judith, Feng, Yu, Freire, Ernesto, Park, Jongwoo, Courter, Joel R., Jones, David M., Robinson, James, Liao, Hua-Xin, Moody, M. Anthony, Permar, Sallie, Haynes, Barton, Smith, Amos B., Wyatt, Richard, Sodroski, Joseph
Publicado em 2014

Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

Por Madani, Navid, Schön, Arne, Princiotto, Amy M., LaLonde, Judith M., Courter, Joel R., Soeta, Takahiro, Ng, Danny, Wang, Liping, Brower, Evan T., Xiang, Shi-Hua, Kwon, Young Do, Huang, Chih-chin, Wyatt, Richard, Kwong, Peter D., Freire, Ernesto, Smith, Amos B., Sodroski, Joseph
Publicado em 2008

Structure-Based Design, Synthesis and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Por LaLonde, Judith M., Kwon, Young Do, Jones, David M., Sun, Alexander W., Courter, Joel R., Soeta, Takahiro, Kobayashi, Toyoharu, Princiotto, Amy M., Wu, Xueling, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Mascola, John R., Sodroski, Joseph, Madani, Navid, Smith, Amos B.
Publicado em 2012