Structural Determinants for Affinity Enhancement of a Dual Antagonist Peptide Entry Inhibitor of Human Immunodeficiency Virus Type-1

Structure-activity correlations were investigated for substituted peptide conjugates that function as dual receptor site antagonists of HIV-1 gp120. A series of peptide conjugates were constructed via click reaction of both aryl and alkyl acetylenes with an internally-incorporated azidoproline 6 der...

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Main Authors: Gopi, Hosahudya, Umashankara, M., Pirrone, Vanessa, LaLonde, Judith, Madani, Navid, Tuzer, Ferit, Baxter, Sabine, Zentner, Isaac, Cocklin, Simon, Jawanda, Navneet, Miller, Shendra R., Schön, Arne, Klein, Jeffrey C., Freire, Ernesto, Krebs, Fred C., Smith, Amos B., Sodroski, Joseph, Chaiken, Irwin
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921370/
https://ncbi.nlm.nih.gov/pubmed/18402432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070814r
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