Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

[Image: see text] This Account provides an overview of a multidisciplinary consortium focused on structure-based strategies to devise small molecule antagonists of HIV-1 entry into human T-cells, which if successful would hold considerable promise for the development of prophylactic modalities to pr...

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Hauptverfasser: Courter, Joel R., Madani, Navid, Sodroski, Joseph, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Hendrickson, Wayne A., Chaiken, Irwin M., LaLonde, Judith M., Smith, Amos B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993944/
https://ncbi.nlm.nih.gov/pubmed/24502450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ar4002735
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