Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition

[Image: see text] The optimization, based on computational, thermodynamic, and crystallographic data, of a series of small-molecule ligands of the Phe43 cavity of the envelope glycoprotein gp120 of human immunodeficiency virus (HIV) has been achieved. Importantly, biological evaluation revealed that...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Melillo, Bruno, Liang, Shuaiyi, Park, Jongwoo, Schön, Arne, Courter, Joel R., LaLonde, Judith M., Wendler, Daniel J., Princiotto, Amy M., Seaman, Michael S., Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A., Smith, Amos B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789667/
https://ncbi.nlm.nih.gov/pubmed/26985324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00471
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