Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition

[Image: see text] The optimization, based on computational, thermodynamic, and crystallographic data, of a series of small-molecule ligands of the Phe43 cavity of the envelope glycoprotein gp120 of human immunodeficiency virus (HIV) has been achieved. Importantly, biological evaluation revealed that...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Med Chem Lett
Autores principales: Melillo, Bruno, Liang, Shuaiyi, Park, Jongwoo, Schön, Arne, Courter, Joel R., LaLonde, Judith M., Wendler, Daniel J., Princiotto, Amy M., Seaman, Michael S., Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A., Smith, Amos B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2016
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789667/
https://ncbi.nlm.nih.gov/pubmed/26985324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00471
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares