Structure-Based Design, Synthesis and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Cellular infection by HIV-1 is initiated with a binding event between the viral envelope glycoprotein gp120 and the cellular receptor protein CD4. The CD4:gp120 interface is dominated by two hotspots: a hydrophobic gp120 cavity capped by Phe43(CD4) and an electrostatic interaction between residues A...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: LaLonde, Judith M., Kwon, Young Do, Jones, David M., Sun, Alexander W., Courter, Joel R., Soeta, Takahiro, Kobayashi, Toyoharu, Princiotto, Amy M., Wu, Xueling, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Mascola, John R., Sodroski, Joseph, Madani, Navid, Smith, Amos B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376652/
https://ncbi.nlm.nih.gov/pubmed/22497421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300265j
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados