Structure-Based Design, Synthesis and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Cellular infection by HIV-1 is initiated with a binding event between the viral envelope glycoprotein gp120 and the cellular receptor protein CD4. The CD4:gp120 interface is dominated by two hotspots: a hydrophobic gp120 cavity capped by Phe43(CD4) and an electrostatic interaction between residues A...

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Bibliografiske detaljer
Main Authors: LaLonde, Judith M., Kwon, Young Do, Jones, David M., Sun, Alexander W., Courter, Joel R., Soeta, Takahiro, Kobayashi, Toyoharu, Princiotto, Amy M., Wu, Xueling, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Mascola, John R., Sodroski, Joseph, Madani, Navid, Smith, Amos B.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376652/
https://ncbi.nlm.nih.gov/pubmed/22497421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300265j
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