Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

The low-molecular-weight compound JRC-II-191 inhibits infection of HIV-1 by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor and is therefore an important lead in the development of a potent viral entry inhibitor. Reported here is the use of two orthogonal screening...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: LaLonde, Judith M., Elban, Mark A., Courter, Joel R., Sugawara, Akihiro, Soeta, Takahiro, Madani, Navid, Princiotto, Amy M., Kwon, Young Do, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Sodroski, Joseph, Smith, Amos B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049263/
https://ncbi.nlm.nih.gov/pubmed/21169023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.11.049
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados