Binding Thermodynamics of a Small-Molecular-Weight CD4 Mimetic to HIV-1 gp120

NBD-556 and the chemically and structurally similar NBD-557 are two low-molecular-weight compounds that reportedly block the interaction between the HIV-1 envelope glycoprotein gp120 and its receptor, CD4. NBD-556 binds to gp120 with a binding affinity of 2.7 × 10(5) M(−1) (K(d) = 3.7 μM) in a proce...

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Bibliographic Details
Main Authors: Schön, Arne, Madani, Navid, Klein, Jeffrey C., Hubicki, Amy, Ng, Danny, Yang, Xinzhen, Smith, Amos B., Sodroski, Joseph, Freire, Ernesto
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504686/
https://ncbi.nlm.nih.gov/pubmed/16953583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061193r
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