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Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120
Human immunodeficiency virus (HIV-1) interaction with the primary receptor, CD4, induces conformational changes in the viral envelope glycoproteins that allow binding to the CCR5 second receptor and virus entry into the host cell. The small molecule NBD-556 mimics CD4 by binding the gp120 exterior e...
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| Asıl Yazarlar: | , , , , , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597202/ https://ncbi.nlm.nih.gov/pubmed/19000821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.09.005 |
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