Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

Human immunodeficiency virus (HIV-1) interaction with the primary receptor, CD4, induces conformational changes in the viral envelope glycoproteins that allow binding to the CCR5 second receptor and virus entry into the host cell. The small molecule NBD-556 mimics CD4 by binding the gp120 exterior e...

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Detaylı Bibliyografya
Asıl Yazarlar: Madani, Navid, Schön, Arne, Princiotto, Amy M., LaLonde, Judith M., Courter, Joel R., Soeta, Takahiro, Ng, Danny, Wang, Liping, Brower, Evan T., Xiang, Shi-Hua, Kwon, Young Do, Huang, Chih-chin, Wyatt, Richard, Kwong, Peter D., Freire, Ernesto, Smith, Amos B., Sodroski, Joseph
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597202/
https://ncbi.nlm.nih.gov/pubmed/19000821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.09.005
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