Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

Human immunodeficiency virus (HIV-1) interaction with the primary receptor, CD4, induces conformational changes in the viral envelope glycoproteins that allow binding to the CCR5 second receptor and virus entry into the host cell. The small molecule NBD-556 mimics CD4 by binding the gp120 exterior e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Madani, Navid, Schön, Arne, Princiotto, Amy M., LaLonde, Judith M., Courter, Joel R., Soeta, Takahiro, Ng, Danny, Wang, Liping, Brower, Evan T., Xiang, Shi-Hua, Kwon, Young Do, Huang, Chih-chin, Wyatt, Richard, Kwong, Peter D., Freire, Ernesto, Smith, Amos B., Sodroski, Joseph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597202/
https://ncbi.nlm.nih.gov/pubmed/19000821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.09.005
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