Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

Binding to the primary receptor CD4 induces conformational changes in the human immunodeficiency virus type 1 (HIV-1) gp120 envelope glycoprotein that allow binding to the coreceptor (CCR5 or CXCR4) and ultimately trigger viral membrane-cell membrane fusion mediated by the gp41 transmembrane envelop...

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Bibliografiske detaljer
Main Authors: Kassa, Aemro, Madani, Navid, Schön, Arne, Haim, Hillel, Finzi, Andrés, Xiang, Shi-Hua, Wang, Liping, Princiotto, Amy, Pancera, Marie, Courter, Joel, Smith, Amos B., Freire, Ernesto, Kwong, Peter D., Sodroski, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738180/
https://ncbi.nlm.nih.gov/pubmed/19535453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00594-09
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