Binding Mode Characterization of NBD Series CD4-Mimetic HIV-1 Entry Inhibitors by X-Ray Structure and Resistance Study

Por Curreli, Francesca, Kwon, Young Do, Zhang, Hongtao, Yang, Yongping, Scacalossi, Daniel, Kwong, Peter D., Debnath, Asim K.
Publicado em 2014

Effects of corticosteroid on the expressions of neuropeptide and cytokine mRNA and on tenocyte viability in lateral epicondylitis

Por Han, Soo Hong, An, Hee Jung, Song, Ji Ye, Shin, Dong Eun, Kwon, Young Do, Shim, Jong Sup, Lee, Soon Chul
Publicado em 2012

Design, synthesis and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1

Por Curreli, Francesca, Choudhury, Spreeha, Pyatkin, Ilya, Zagorodnikov, Victor P., Bulay, Anna Khulianova, Altieri, Andrea, Kwon, Young Do, Kwong, Peter D., Debnath, Asim K.
Publicado em 2012

Discovery and Characterization of Novel MicroRNAs During Endothelial Differentiation of Human Embryonic Stem Cells

Por Yoo, Jung Ki, Kim, Jumi, Choi, Seong–Jun, Noh, Hye Min, Kwon, Young Do, Yoo, Hanna, Yi, Hyo seon, Chung, Hyung Min, Kim, Jin Kyeoung
Publicado em 2012

MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance

Por Park, Young Tae, Jeong, Ju-yeon, Lee, Mi-jung, Kim, Kwang-il, Kim, Tae-Heon, Kwon, Young-do, Lee, Chan, Kim, Ok Jun, An, Hee-Jung
Publicado em 2013

Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å co-crystal structure of gp120 and M48U1

Por Acharya, Priyamvada, Luongo, Timothy, Louder, Mark K., McKee, Krisha, Yang, Yongping, Kwon, Young Do, Mascola, John R., Kessler, Pascal, Martin, Loïc, Kwong, Peter D.
Publicado em 2013

Enhancing the Solubility of HIV-1-neutralizing Antibody 10E8

Por Kwon, Young Do, Georgiev, Ivelin S., Zhang, Baoshan, McKee, Krisha, O'Dell, Sijy, Druz, Alex, Shi, Wei, Connors, Mark, Mascola, John R., Kwong, Peter D.
Publicado no AIDS Res Hum Retroviruses (2014)

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

Por Curreli, Francesca, Kwon, Young Do, Zhang, Hongtao, Scacalossi, Daniel, Belov, Dmitry S., Tikhonov, Artur A., Andreev, Ivan A., Altieri, Andrea, Kurkin, Alexander V., Kwong, Peter D., Debnath, Asim K.
Publicado no J Med Chem (2015)

Combinatorial optimization of a CD4-mimetic miniprotein and co-crystal structures with HIV-1 gp120 envelope glycoprotein

Por Stricher, François, Huang, Chih-chin, Descours, Anne, Duquesnoy, Sophie, Combes, Olivier, Decker, Julie M., Kwon, Young Do, Lusso, Paolo, Shaw, George M., Vita, Claudio, Kwong, Peter D., Martin, Loïc
Publicado em 2008

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

Por Kwon, Young Do, LaLonde, Judith M., Yang, Yongping, Elban, Mark A., Sugawara, Akihiro, Courter, Joel R., Jones, David M., Smith, Amos B., Debnath, Asim K., Kwong, Peter D.
Publicado em 2014

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

Por LaLonde, Judith M., Elban, Mark A., Courter, Joel R., Sugawara, Akihiro, Soeta, Takahiro, Madani, Navid, Princiotto, Amy M., Kwon, Young Do, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Sodroski, Joseph, Smith, Amos B.
Publicado em 2010

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Por Pancera, Marie, Majeed, Shahzad, Ban, Yih-En Andrew, Chen, Lei, Huang, Chih-chin, Kong, Leopold, Kwon, Young Do, Stuckey, Jonathan, Zhou, Tongqing, Robinson, James E., Schief, William R., Sodroski, Joseph, Wyatt, Richard, Kwong, Peter D.
Publicado em 2009

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains

Por Chuang, Gwo-Yu, Acharya, Priyamvada, Schmidt, Stephen D., Yang, Yongping, Louder, Mark K., Zhou, Tongqing, Kwon, Young Do, Pancera, Marie, Bailer, Robert T., Doria-Rose, Nicole A., Nussenzweig, Michel C., Mascola, John R., Kwong, Peter D., Georgiev, Ivelin S.
Publicado em 2013

Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

Por Madani, Navid, Schön, Arne, Princiotto, Amy M., LaLonde, Judith M., Courter, Joel R., Soeta, Takahiro, Ng, Danny, Wang, Liping, Brower, Evan T., Xiang, Shi-Hua, Kwon, Young Do, Huang, Chih-chin, Wyatt, Richard, Kwong, Peter D., Freire, Ernesto, Smith, Amos B., Sodroski, Joseph
Publicado em 2008

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Por Zhou, Tongqing, Georgiev, Ivelin, Wu, Xueling, Yang, Zhi-Yong, Dai, Kaifan, Finzi, Andrés, Kwon, Young Do, Scheid, Johannes, Shi, Wei, Xu, Ling, Yang, Yongping, Zhu, Jiang, Nussenzweig, Michel C., Sodroski, Joseph, Shapiro, Lawrence, Nabel, Gary J., Mascola, John R., Kwong, Peter D.
Publicado em 2010

Structure-Based Design, Synthesis and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Por LaLonde, Judith M., Kwon, Young Do, Jones, David M., Sun, Alexander W., Courter, Joel R., Soeta, Takahiro, Kobayashi, Toyoharu, Princiotto, Amy M., Wu, Xueling, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Mascola, John R., Sodroski, Joseph, Madani, Navid, Smith, Amos B.
Publicado em 2012

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Por Kwon, Young Do, Finzi, Andrés, Wu, Xueling, Dogo-Isonagie, Cajetan, Lee, Lawrence K., Moore, Lucas R., Schmidt, Stephen D., Stuckey, Jonathan, Yang, Yongping, Zhou, Tongqing, Zhu, Jiang, Vicic, David A., Debnath, Asim K., Shapiro, Lawrence, Bewley, Carole A., Mascola, John R., Sodroski, Joseph G., Kwong, Peter D.
Publicado em 2012

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Por Chen, Lei, Kwon, Young Do, Zhou, Tongqing, Wu, Xueling, O'Dell, Sijy, Cavacini, Lisa, Hessell, Ann J., Pancera, Marie, Tang, Min, Xu, Ling, Yang, Zhi-Yong, Zhang, Mei-Yun, Arthos, James, Burton, Dennis R., Dimitrov, Dimiter S., Nabel, Gary J., Posner, Marshall R., Sodroski, Joseph, Wyatt, Richard, Mascola, John R., Kwong, Peter D.
Publicado em 2009

Eliminating antibody polyreactivity through addition of N-linked glycosylation

Por Chuang, Gwo-Yu, Zhang, Baoshan, McKee, Krisha, O'Dell, Sijy, Kwon, Young Do, Zhou, Tongqing, Blinn, Julie, Lloyd, Krissey, Parks, Robert, Von Holle, Tarra, Ko, Sung-Youl, Kong, Wing-Pui, Pegu, Amarendra, Wang, Keyun, Baruah, Kavitha, Crispin, Max, Mascola, John R, Moody, M Anthony, Haynes, Barton F, Georgiev, Ivelin S, Kwong, Peter D
Publicado no Protein Sci (2015)

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

Por Acharya, Priyamvada, Tolbert, William D., Gohain, Neelakshi, Wu, Xueji, Yu, Lei, Liu, Tongyun, Huang, Wensheng, Huang, Chih-chin, Kwon, Young Do, Louder, Robert K., Luongo, Timothy S., McLellan, Jason S., Pancera, Marie, Yang, Yongping, Zhang, Baoshan, Flinko, Robin, Foulke, James S., Sajadi, Mohammad M., Kamin-Lewis, Roberta, Robinson, James E., Martin, Loïc, Kwong, Peter D., Guan, Yongjun, DeVico, Anthony L., Lewis, George K., Pazgier, Marzena
Publicado no J Virol (2014)