Eliminating antibody polyreactivity through addition of N-linked glycosylation

Antibody polyreactivity can be an obstacle to translating a candidate antibody into a clinical product. Standard tests such as antibody binding to cardiolipin, HEp-2 cells, or nuclear antigens provide measures of polyreactivity, but its causes and the means to resolve are often unclear. Here we pres...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Chuang, Gwo-Yu, Zhang, Baoshan, McKee, Krisha, O'Dell, Sijy, Kwon, Young Do, Zhou, Tongqing, Blinn, Julie, Lloyd, Krissey, Parks, Robert, Von Holle, Tarra, Ko, Sung-Youl, Kong, Wing-Pui, Pegu, Amarendra, Wang, Keyun, Baruah, Kavitha, Crispin, Max, Mascola, John R, Moody, M Anthony, Haynes, Barton F, Georgiev, Ivelin S, Kwong, Peter D
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Methods and Applications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456115/
https://ncbi.nlm.nih.gov/pubmed/25800131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2682
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