Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

Antibodies m66.6 and 2F5 are the only effective human HIV-1-neutralizing antibodies reported thus far to recognize the N-terminal region of the membrane-proximal external region (MPER) of the gp41 subunit of the HIV-1 envelope glycoprotein. Although 2F5 has been extensively characterized, much less...

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Bibliographische Detailangaben
Hauptverfasser: Ofek, Gilad, Zirkle, Brett, Yang, Yongping, Zhu, Zhongyu, McKee, Krisha, Zhang, Baoshan, Chuang, Gwo-Yu, Georgiev, Ivelin S., O'Dell, Sijy, Doria-Rose, Nicole, Mascola, John R., Dimitrov, Dimiter S., Kwong, Peter D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958054/
https://ncbi.nlm.nih.gov/pubmed/24335316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02837-13
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