Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

The conserved HIV-1 site of coreceptor binding is protected from antibody-directed neutralization by conformational and steric restrictions. While inaccessible to most human antibodies, the coreceptor site has been shown to be accessed by antibody fragments. In this study, we used X-ray crystallogra...

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Główni autorzy: Acharya, Priyamvada, Luongo, Timothy S., Georgiev, Ivelin S., Matz, Julie, Schmidt, Stephen D., Louder, Mark K., Kessler, Pascal, Yang, Yongping, McKee, Krisha, O'Dell, Sijy, Chen, Lei, Baty, Daniel, Chames, Patrick, Martin, Loïc, Mascola, John R., Kwong, Peter D.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology 2013
Hasła przedmiotowe:
Vaccines and Antiviral Agents
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753989/
https://ncbi.nlm.nih.gov/pubmed/23843638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01332-13
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