The debate continues – What is the role of MCU and mitochondrial calcium uptake in the heart?

Por Garbincius, Joanne F., Luongo, Timothy S., Elrod, John W.
Publicado no J Mol Cell Cardiol (2020)

Sources and Importance of Mitochondrial NAD

Por Baur, Joseph, Luongo, Timothy, Eller, Jared, Lu, Mu-Jie, Perry, Caroline, Cambronne, Lulu
Publicado no Innov Aging (2020)

Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy

Por Woodall, Benjamin P., Woodall, Meryl C., Luongo, Timothy S., Grisanti, Laurel A., Tilley, Douglas G., Elrod, John W., Koch, Walter J.
Publicado no J Biol Chem (2016)

mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia

Por Paolella, Lauren M., Mukherjee, Sarmistha, Tran, Cassie M., Bellaver, Bruna, Hugo, Mindy, Luongo, Timothy S., Shewale, Swapnil V., Lu, Wenyun, Chellappa, Karthikeyani, Baur, Joseph A.
Publicado no Mol Metab (2019)

MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress

Por Lambert, Jonathan P., Luongo, Timothy S., Tomar, Dhanendra, Jadiya, Pooja, Gao, Erhe, Zhang, Xueqian, Lucchese, Anna Maria, Kolmetzky, Devin W., Shah, Neil S., Elrod, John W.
Publicado no Circulation (2019)

Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å co-crystal structure of gp120 and M48U1

Por Acharya, Priyamvada, Luongo, Timothy, Louder, Mark K., McKee, Krisha, Yang, Yongping, Kwon, Young Do, Mascola, John R., Kessler, Pascal, Martin, Loïc, Kwong, Peter D.
Publicado em 2013

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Por Jadiya, Pooja, Kolmetzky, Devin W., Tomar, Dhanendra, Di Meco, Antonio, Lombardi, Alyssa A., Lambert, Jonathan P., Luongo, Timothy S., Ludtmann, Marthe H., Praticò, Domenico, Elrod, John W.
Publicado no Nat Commun (2019)

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

Por Luongo, Timothy S., Lambert, Jonathan P., Yuan, Ancai, Zhang, Xueqian, Gross, Polina, Song, Jianliang, Shanmughapriya, Santhanam, Gao, Erhe, Jain, Mohit, Houser, Steven R., Koch, Walter J., Cheung, Joseph Y., Madesh, Muniswamy, Elrod, John W.
Publicado no Cell Rep (2015)

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

Por Acharya, Priyamvada, Luongo, Timothy S., Georgiev, Ivelin S., Matz, Julie, Schmidt, Stephen D., Louder, Mark K., Kessler, Pascal, Yang, Yongping, McKee, Krisha, O'Dell, Sijy, Chen, Lei, Baty, Daniel, Chames, Patrick, Martin, Loïc, Mascola, John R., Kwong, Peter D.
Publicado em 2013

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers

Por Acharya, Priyamvada, Zhou, Tongqing, Soto, Cinque, Chen, Lei, Luongo, Timothy S., Moquin, Stephanie, Georgiev, Ivelin S., Schmidt, Stephen D., Louder, Mark K., Joyce, M. Gordon, Yang, Yongping, Zhang, Baoshan, Scheid, Johannes, Nussenzweig, Michel C., Mascola, John R., Kwong, Peter D.
Publicado no AIDS Res Hum Retroviruses (2014)

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor...

Por Acharya, Priyamvada, Luongo, Timothy S., Georgiev, Ivelin S., Matz, Julie, Schmidt, Stephen D., Louder, Mark K., Kessler, Pascal, Yang, Yongping, McKee, Krisha, O'Dell, Sijy, Chen, Lei, Baty, Daniel, Chames, Patrick, Martin, Loïc, Mascola, John R., Kwong, Peter D.
Publicado no J Virol (2014)

The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability

Por Luongo, Timothy S., Lambert, Jonathan P., Gross, Polina, Nwokedi, Mary, Lombardi, Alyssa A., Shanmughapriya, Santhanam, Carpenter, April C., Kolmetzky, Devin, Gao, Erhe, van Berlo, Jop H., Tsai, Emily J., Molkentin, Jeffery D., Chen, Xiongwen, Madesh, Muniswamy, Houser, Steven R., Elrod, John W.
Publicado no Nature (2017)

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Por Lombardi, Alyssa A., Gibb, Andrew A., Arif, Ehtesham, Kolmetzky, Devin W., Tomar, Dhanendra, Luongo, Timothy S., Jadiya, Pooja, Murray, Emma K., Lorkiewicz, Pawel K., Hajnóczky, György, Murphy, Elizabeth, Arany, Zoltan P., Kelly, Daniel P., Margulies, Kenneth B., Hill, Bradford G., Elrod, John W.
Publicado no Nat Commun (2019)

Structure-Based Identification and Neutralization Mechanism of Tyrosine-Sulfate Mimetics that Inhibit HIV-1 Entry

Por Acharya, Priyamvada, Dogo-Isonagie, Cajetan, Lalonde, Judith M., Lam, Son N., Leslie, George J., Louder, Mark K., Frye, Leah L., Debnath, Asim K., Greenwood, Jeremy R., Luongo, Timothy S., Martin, Loïc, Watts, K. Shawn, Hoxie, James A., Mascola, John R., Bewley, Carole A., Kwong, Peter D.
Publicado em 2011

SLC25A51 is a mammalian mitochondrial NAD(+) transporter

Por Luongo, Timothy S., Eller, Jared M., Lu, Mu-Jie, Niere, Marc, Raith, Fabio, Perry, Caroline, Bornstein, Marc R., Oliphint, Paul, Wang, Lin, McReynolds, Melanie R., Migaud, Marie E., Rabinowitz, Joshua D., Johnson, F. Brad, Johnsson, Kai, Ziegler, Mathias, Cambronne, Xiaolu A., Baur, Joseph A.
Publicado no Nature (2020)

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

Por Khan, Mohsin, Nickoloff, Emily, Abramova, Tatiana, Johnson, Jennifer, Verma, Suresh Kumar, Krishnamurthy, Prasanna, Mackie, Alexander Roy, Vaughan, Erin, Garikipati, Venkata Naga Srikanth, Benedict, Cynthia, Ramirez, Veronica, Lambers, Erin, Ito, Aiko, Gao, Erhe, Misener, Sol, Luongo, Timothy, Elrod, John, Qin, Gangjian, Houser, Steven R, Koch, Walter J, Kishore, Raj
Publicado no Circ Res (2015)

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

Por Acharya, Priyamvada, Tolbert, William D., Gohain, Neelakshi, Wu, Xueji, Yu, Lei, Liu, Tongyun, Huang, Wensheng, Huang, Chih-chin, Kwon, Young Do, Louder, Robert K., Luongo, Timothy S., McLellan, Jason S., Pancera, Marie, Yang, Yongping, Zhang, Baoshan, Flinko, Robin, Foulke, James S., Sajadi, Mohammad M., Kamin-Lewis, Roberta, Robinson, James E., Martin, Loïc, Kwong, Peter D., Guan, Yongjun, DeVico, Anthony L., Lewis, George K., Pazgier, Marzena
Publicado no J Virol (2014)

Multi-donor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for Effective HIV-1 Neutralization by VRCO1-class Antibodies

Por Zhou, Tongqing, Zhu, Jiang, Wu, Xueling, Moquin, Stephanie, Zhang, Baoshan, Acharya, Priyamvada, Georgiev, Ivelin S., Altae-Tran, Han R., Chuang, Gwo-Yu, Joyce, M. Gordon, Kwon, Young Do, Longo, Nancy S., Louder, Mark K., Luongo, Timothy, McKee, Krisha, Schramm, Chaim A., Skinner, Jeff, Yang, Yongping, Yang, Zhongjia, Zhang, Zhenhai, Zheng, Anqi, Bonsignori, Mattia, Haynes, Barton F., Scheid, Johannes F., Nussenzweig, Michel C., Simek, Melissa, Burton, Dennis R., Koff, Wayne C., Mullikin, James C., Connors, Mark, Shapiro, Lawrence, Nabel, Gary J., Mascola, John R., Kwong, Peter D.
Publicado em 2013

MCUR1 is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

Por Tomar, Dhanendra, Dong, Zhiwei, Shanmughapriya, Santhanam, Koch, Diana A., Thomas, Toby, Hoffman, Nicholas E., Timbalia, Shrishiv A., Goldman, Samuel J., Breves, Sara L., Corbally, Daniel P., Nemani, Neeharika, Fairweather, Joseph P., Cutri, Allison R., Zhang, Xueqian, Song, Jianliang, Prado, Fabian J., Huang, Jianhe, Barrero, Carlos, Rabinowitz, Joseph E., Luongo, Timothy S., Schumacher, Sarah M., Rockman, Michael, Dietrich, Alexander, Merali, Salim, Caplan, Jeffrey, Stathopulos, Peter, Ahima, Rexford S., Cheung, Joseph Y., Houser, Steven R., Koch, Walter J., Patel, Vickas, Gohil, Vishal M., Elrod, John W., Rajan, Sudarsan, Madesh, Muniswamy
Publicado no Cell Rep (2016)

Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors

Por Zhou, Tongqing, Lynch, Rebecca M., Chen, Lei, Acharya, Priyamvada, Wu, Xueling, Doria-Rose, Nicole A., Joyce, M. Gordon, Lingwood, Daniel, Soto, Cinque, Bailer, Robert T., Ernandes, Michael J., Kong, Rui, Longo, Nancy S., Louder, Mark K., McKee, Krisha, O’Dell, Sijy, Schmidt, Stephen D., Tran, Lillian, Yang, Zhongjia, Druz, Aliaksandr, Luongo, Timothy S., Moquin, Stephanie, Srivatsan, Sanjay, Yang, Yongping, Zhang, Baoshan, Zheng, Anqi, Pancera, Marie, Kirys, Tatsiana, Georgiev, Ivelin S., Gindin, Tatyana, Peng, Hung-Pin, Yang, An-Suei, Mullikin, James C., Gray, Matthew D., Stamatatos, Leonidas, Burton, Dennis R., Koff, Wayne C., Cohen, Myron S., Haynes, Barton F., Casazza, Joseph P., Connors, Mark, Corti, Davide, Lanzavecchia, Antonio, Sattentau, Quentin J., Weiss, Robin A., West, Anthony P., Bjorkman, Pamela J., Scheid, Johannes F., Nussenzweig, Michel C., Shapiro, Lawrence, Mascola, John R., Kwong, Peter D.
Publicado no Cell (2015)