Structure-Based Identification and Neutralization Mechanism of Tyrosine-Sulfate Mimetics that Inhibit HIV-1 Entry

Tyrosine sulfate-mediated interactions play an important role in HIV-1 entry. After engaging the CD4 receptor at the cell surface, the HIV-1 gp120 glycoprotein binds to the CCR5 co-receptor via an interaction that requires two tyrosine-sulfates, at positions 10 and 14 in the CCR5-N terminus. Buildin...

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Main Authors: Acharya, Priyamvada, Dogo-Isonagie, Cajetan, Lalonde, Judith M., Lam, Son N., Leslie, George J., Louder, Mark K., Frye, Leah L., Debnath, Asim K., Greenwood, Jeremy R., Luongo, Timothy S., Martin, Loïc, Watts, K. Shawn, Hoxie, James A., Mascola, John R., Bewley, Carole A., Kwong, Peter D.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205951/
https://ncbi.nlm.nih.gov/pubmed/21793507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200068b
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