Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry

In the absence of a cure or vaccine for HIV/AIDS, small molecule inhibitors remain an attractive choice for antiviral therapeutics. Recent structural and functional studies of the HIV-1 surface envelope glycoprotein gp120 have revealed sites of vulnerability that can be targeted by small molecule an...

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Publicat a:Bioorg Med Chem
Autors principals: Dogo-Isonagie, Cajetan, Lee, Su-Lin, Lohith, Katheryn, Liu, Hongbing, Mandadapu, Sivakoteswara R., Lusvarghi, Sabrina, O’Connor, Robert D., Bewley, Carole A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261409/
https://ncbi.nlm.nih.gov/pubmed/26968647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.02.044
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